ProLymphNano: Unlocking the therapeutic potential of the lymphatic system
An injectable drug delivery platform designed to enhance lymphatic targeting and enable sustained therapeutic delivery.
The lymphatic system is a critical network of vessels, tissues, and organs that regulates fluid balance, immune function, and inflammation throughout the body. It also plays a central role in the development and progression of numerous diseases, including lymphatic disorders, autoimmune diseases, and cancers.
Despite its importance, the lymphatic system remains challenging to target with conventional medicines. Following administration, drugs enter the bloodstream, limiting their exposure within lymphatic tissues. This presents a significant opportunity for drug delivery technologies designed to enhance lymphatic uptake and improve therapeutic outcomes.
Unlocking the Potential of the Lymphatic System
Conventional drug delivery favors bloodstream uptake
Designed for Sustained Lymphatic Delivery
ProLymphNano is an injectable drug delivery platform built around a biodegradable, thermoresponsive polymer that forms a hydrogel depot following subcutaneous administration. As the hydrogel degrades, the material forms drug-loaded nanoparticles designed for uptake into the lymphatic system.
This approach combines sustained drug release with lymphatic targeting, offering the potential to increase therapeutic exposure within lymphatic tissues while reducing systemic exposure.
Hydrogel degradation leads to sustained release of drug-loaded nanoparticles into lymphatics
Incorporate drug by simple mixing; deliver via subQ injection.
Hydrogel forms at
body temperature
Platform Advantages
Scientific Publications
Thermosensitive Hydrogel Sustaining the Release of Lymph-Draining Oligonucleotide Adjuvant Polyplex Micelles Improves Systemic Cancer Immunotherapy
ACS Nano · 2025
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Sustained release hydrogel for durable locoregional chemoimmunotherapy for BRAF-mutated melanoma
Journal of Controlled Release · 2023
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Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy
Nature Communications · 2022
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